BACKGROUND:\ud\udExtramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.\udMAIN OBSERVATIONS:\ud\udWe present a case of a 59-year-old woman with primary extramammary Paget's disease of the vulva, in which a conservative approach to therapy was desired, and who underwent complete and stable remission with imiquimod cream. We also review the previous reports of patients with extramammary Paget's disease treated with imiquimod cream.\udCONCLUSIONS:\ud\udImiquimod therapy may be an alternative for primary as well as recurring extramammary Paget's disease. Treatment-associated morbidity is minimal compared with other therapies, such as surgery which may be debilitating.
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机译:背景:乳房外佩吉特氏病是一种皮肤肿瘤,表现为红斑结patches斑块和斑块,使人联想起接触性皮炎或银屑病,这可能是一种以组织保存方式治疗的挑战。这种罕见疾病最常见的部位是肛门生殖器区域。手术被认为是金标准疗法。在过去的几年中,已报道了局部使用咪喹莫特乳膏治疗这种病的情况。\ ud主要观察:\ ud \ ud我们介绍了一位59岁的女性,患有外阴原发性乳腺Paget病,希望采用保守的治疗方法,并接受咪喹莫特乳膏彻底稳定的缓解。我们还回顾了以前用咪喹莫特乳膏治疗的乳房外Paget病患者的报道。\ ud结论:\ ud \ ud咪喹莫特疗法可能是原发性和复发性乳房外Paget病的替代方法。与其他疗法(例如可能使人衰弱的手术)相比,与治疗相关的发病率极低。
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